I think 'active player' can mean a lot of different things. For me that would mean playing with my Quintet, my Trio, or Recording. Here's what I use.
Quintet:
1) Ash body Strat with Van Zandt classic plus pickups
2) '00 Bluesbird with Seymour Duncan pickups with changed pots converted to vintage Les Paul wiring.
3) small Fender amps, Princeton R, Deluxe R., mic'd
Quintet plays '56-'76 (pre-Tom Petty) rock, blues, gospel, blue-grass, standards, etc. I used to use an ac/elec dreadnought, but the medium strings beat up my hands and the lead lines were harder to play and didn't cut through the mix.
Trio:
1) Tele,
2) Bluesbird,
3) X-170T
4) baritone electric to be named later, with capo.
5) same fenders, plus a Vox AC-30 for loud gigs, also mic'd.
Trio plays blues and more basic 60s-70s rock and roll, like the Stones, Howling' Wolf, B.B. King, etc., so I need a few differently purposed guitars; one tuned like Keith, one with a Bigsby, and whatever guitar neck feels easiest to play that day for shuffle chords at the bottom of the neck near the nut (did I mention arthritis?).
Recording:
Electrics: Bluesbird, Tele, ES-335, Strat, Ricky 12, nylon classical, plus short and long-scale basses.
Acoustics: either an OO or OOO-sized guitar, plus one Dread (I'd want the two acoustics to have different scale lengths), a 12-string acoustic
Other: some electric keys, ukulele, mandolin. Drums if you are able to have them in your house, rehearsal room, etc.
I'd want a keyboard for guest players and the uke and the mando for different sounds to 'change up' the overall mix.